ABSTRACT
Objective:To investigate the relationship between prolonged PR interval and carotid atherosclerosis(CAS)in middle-aged and elderly patients with type 2 diabetes mellitus(T2DM).Methods:A total of 537 middle-aged and elderly inpatients with T2DM in the Southern Branch of the Sixth People′s Hospital of Shanghai Jiaotong University from January 2019 to January 2021 were selected as the research objects. Color Doppler ultrasound was used to detect bilateral carotid artery intima-media thickness(CIMT). The subjects were divided into carotid atherosclerosis group(CAS group, n=352)and non-carotid atherosclerosis group(NCAS group, n=185). The difference in the PR interval of ECG between the two groups was compared. Pearson or Spearman rank correlation analysis was used for evaluating the correlation of PR interval and CAS lesions with various clinical index. The relationship between PR interval and CAS lesions was adopted by multivariate logistic regression analysis. Results:The average PR interval of middle-aged and elderly patients with T2DM was(164.57±23.02)ms. The average PR interval in CAS group was significantly higher than that in NCAS group [(169.76±24.28) vs (154.70±16.42)ms, P<0.01]. The results of multifactorial logistic regression analysis showed that age, low density lipoprotein-cholesterol, serum osteocalcin, and PR interval were independent factors influencing the development of CAS lesions in middle-aged and elderly patients with T2DM( OR=1.079, 1.936, 0.879, 1.039, respectively, P<0.05 or P<0.01)where each 1 ms increase in PR interval was associated with a 3.9% increase in the risk of CAS in middle-aged and elderly patients with T2DM( OR=1.039, 95% CI 1.006-1.073, P=0.020). Multivariate logistic regression analysis showed that middle-aged and elderly type 2 diabetic patients with PR interval≥158 ms were 4.072 times more likely to have CAS lesions than those with PR interval<158 ms( OR=4.072, 95% CI 1.417-11.702, P<0.01). Conclusion:The PR interval of electrocardiogram is correlated with CAS lesions in middle-aged and elderly patients with T2DM. Middle-aged and elderly type 2 diabetic patients with significantly prolonged PR interval should be reminded to screen for CAS lesions early.
ABSTRACT
Objective To evaluate the clinical effects of Wenshen-Zhuanggu decoction combined with calcium preparations and vitamin D in the treatment of senile osteoporosis. Methods A total of 82 patients with osteoporosis were randomly divided into the control group and the observation group, 41 in each group. The control group was given conventional treatment (calcium preparations, vitamin D). Based on the treatment of control group, the observation group was combined with traditional Chinese medicine (TCM) formula Wenshen-Zhuanggu decoction. Both groups were treated for 10 weeks, and followed up for 3 months. The improvement of osteoporosis, bone function related indexes bone mineral density (BMD), serum bone gla protein (BGP), serum bone alkaline phosphatase (BALP) and incidence of osteoportic fractures and adverse reactions in the two groups were observed. Results The effective rate of symptom remission in the observation group was 90.24% (37/41) while in the control group was 70.73% (29/41) (χ2=4.970, P<0.05), and the bone function related indexes of both groups (BMD, BGP, BALP) were significantly improved after treatment. Compared with the control group, the BMD (0.84 ± 0.05 g/cm2 vs. 0.78 ± 0.06 g/cm2, t=4.919), BGP (28.64 ± 12.14 ng/ml vs. 21.32 ± 11.25 ng/ml, t=2.832) and BALP (18.11 ± 6.15 U/L vs. 14.54 ± 6.21 U/L, t=2.615) in the observation group were significantly higher than those in the control group (P<0.05). The incidence rates of adverse reactions (7.32%vs. 24.39%) and osteoportic fractures (9.76%vs. 26.83%) in the observation group were significantly lower than those in the control group (P<0.05). Conclusions Wenshen-Zhuanggu decoction combined with calcium preparations and vitamin D in the treatment of senile osteoporosis can effectively alleviate symptoms and preventing senile OP fractures..